Study of graft arteries – Introduction

Professor Brian Buxton
Professor Brian Buxton
Professor Brian Buxton and Dr. Permyos Ruengsakulrach (Lek) were heart surgeons at the Austin and Repatriation Medical Centre at the time of this study. Coronary bypass surgery involves taking pieces of artery or vein from elsewhere in the body (either the chest, arm or leg) and using them to replace blocked arteries in the heart. This means the surgeon needs to choose which artery or vein to use for a Coronary Artery Bypass Graft (CABG). Brian and Lek wanted to compare abnormalities in the internal thoracic artery (from the chest) and the radial artery (from the arm). They also wanted to investigate risk factors for developing arterial abnormalities. Standard CABG uses the left internal thoracic artery as the first choice but may use a radial artery or the right internal thoracic artery if further grafts are required.

Dr. Permyos Lek
Dr. Permyos Lek

The key question that Brian and Lek wanted to answer was:

In the same patients, were the levels of disease similar in the radial artery and the internal thoracic artery?


Early 1995 Study design
Early 1995 Application to Ethics Committee
May, 1995 Data collection starts
October, 1997 Data collection finishes
1997 – 1998 Data analysis
June, 1998 Write up for publication
November, 1999 Article appears in Circulation